Despite, In Spite Of, Although & Even Though.

Despite and In Spite Of have the same meaning and are used with the same grammar.

Despite + Noun not despite of

Despite the rain, we went to the beach.
Despite the time, we continued talking.
Despite + Gerund not despite of

Despite losing her wallet, Jane was in a good mood.
Despite waiting for an hour, we were glad to sit in the train.

Despite + the fact that + Sentence

Despite the fact that it was raining, we went to the beach.
Despite the fact that Jane lost her wallet, she was in a good mood.

In spite of + Noun

In spite of the rain, we went to the beach.
In spite of the time, we continued talking.

In spite of + Gerund

In spite of losing her wallet, Jane was in a good mood.
In spite of waiting for an hour, we were glad to sit in the train.

In spite of + the fact that + Sentence

In spite of the fact that it was raining, we went to the beach.
In spite of the fact that Jane lost her wallet, she was in a good mood.

Although & even though have the same structure, but even though has a stronger meaning. We use although (or) even though + sentence

Although it was raining, we went to the beach.
Although Jane lost her wallet, she was in a good mood.
Even though it was raining, we went to the beach.
Even though Jane lost her wallet, she was in a good mood.